Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.39 |
| ▸ | RORC | P51449 | 5/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 4/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5506705 | 0.86 | KEAP1 (0.38) | RORCMMP2HPGD | |
| SCHEMBL5029070 | 0.84 | MMP2 (0.43) | RORCMMP2HPGD | |
| SCHEMBL7458622 | 0.80 | RORC (0.45) | MCL1BCL2L1RORCHPGD | |
| SCHEMBL5981554 | 0.79 | MCL1 (0.39) | MCL1BCL2L1HPGD | |
| SCHEMBL4854967 | 0.78 | ESR1 (0.44) | — | |
| SCHEMBL7455250 | 0.75 | ADAM17 (0.37) | MCL1BCL2L1MMP2HPGD | |
| SCHEMBL5691126 | 0.74 | KEAP1 (0.39) | RORCMMP2HPGD | |
| Hydrochloric Acid SCHEMBL6394136 | 0.74 | KEAP1 (0.35) | MCL1RORCMMP2 | |
| SCHEMBL6390909 | 0.73 | HSD11B1 (0.37) | RORCMMP2HPGD | |
| SCHEMBL4853866 | 0.73 | RORC (0.44) | MCL1BCL2L1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0813543-B1 | BIS-AMINO ACID HYDROXYETHYLAMINO SULFONAMIDE RETROVIRAL PROTEASE INHIBITORS | SEARLE LLC (US) | 2005-09-14 | — | — | EP | disclosed |
| EP-1076062-A1 | Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 2001-02-14 | — | — | EP | disclosed |