Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6368497 | 0.79 | GFER (0.39) | HRH3TSHRCA1CA2CA12 | |
| SCHEMBL6369532 | 0.79 | TMEM97 (0.43) | NPC1RAB9ASMN1; SMN2SIGMAR1 | |
| SCHEMBL24891637 | 0.73 | PTGIR (0.53) | KCNH2TSHRKCNJ1CA1CA2 | |
| SCHEMBL29227038 | 0.73 | POLB (0.50) | KCNH2TSHRKCNJ1CA1CA2 | |
| SCHEMBL9628053 | 0.70 | KCNH2 (0.73) | HRH3KCNH2TSHRKCNJ1CA1 | |
| SCHEMBL6375437 | 0.70 | IDH1 (0.43) | TSHRMEN1KMT2APOLBNPC1 | |
| SCHEMBL12693810 | 0.69 | TSHR (0.60) | HRH3KCNH2TSHRKCNJ1CA1 | |
| SCHEMBL28121312 | 0.69 | PTPRF (0.71) | TSHRMEN1KMT2APOLBNPC1 | |
| SCHEMBL1847096 | 0.69 | TSHR (0.64) | HRH3KCNH2TSHRKCNJ1KMT2A | |
| SCHEMBL3292782 | 0.68 | TSHR (0.75) | HRH3KCNH2TSHRKCNJ1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050119461-A1 | Novel receptor, and compounds which bind thereto | THE UNIVERSITY OF MELBOURNE | 2005-06-02 | — | — | US | disclosed |
| EP-1044194-A4 | RECEPTOR WITH AN AFFINITY FOR COMPOUNDS OF THE OXAZOLINE CLASS | UNIV MELBOURNE (AU) | 2002-01-09 | — | — | EP | disclosed |
| EP-1044194-A1 | RECEPTOR WITH AN AFFINITY FOR COMPOUNDS OF THE OXAZOLINE CLASS | THE UNIVERSITY OF MELBOURNE (AU) | 2000-10-18 | — | — | EP | disclosed |
| WO-1999024411-A1 | RECEPTOR WITH AN AFFINITY FOR COMPOUNDS OF THE OXAZOLINE CLASS | THE UNIVERSITY OF MELBOURNE (AU) | 1999-05-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119461-A1 | Novel receptor, and compounds which bind thereto | GPR27, GPR174, GPR52 | HRH3 639/4885KCNH2 1423/4885TSHR 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.