Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PEPD | P12955 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.44 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8350809 | 0.84 | POLB (0.49) | POLBFKBP1AALDH1A1LMNARAB9A | |
| SCHEMBL17751443 | 0.84 | POLB (0.49) | POLBFKBP1AALDH1A1LMNARAB9A | |
| SCHEMBL12343829 | 0.83 | ACE (0.46) | ACEDPP4DPP8DPP7 | |
| SCHEMBL12343757 | 0.83 | ACE (0.46) | ACEDPP4DPP8DPP7 | |
| SCHEMBL16656666 | 0.83 | ACE (0.46) | ACEDPP4DPP8DPP7 | |
| SCHEMBL7364621 | 0.83 | ACE (0.62) | LMNARAB9APEPDACE | |
| SCHEMBL7333530 | 0.83 | POLB (0.54) | POLBFKBP1AALDH1A1LMNARAB9A | |
| SCHEMBL13662643 | 0.83 | FKBP1A (0.55) | POLBFKBP1AALDH1A1LMNARAB9A | |
| SCHEMBL7333522 | 0.83 | POLB (0.54) | POLBFKBP1AALDH1A1LMNARAB9A | |
| SCHEMBL4179454 | 0.83 | FKBP1A (0.55) | POLBFKBP1AALDH1A1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341007-B1 | MALT1 INHIBITORS AND USES THEREOF | UNIV CORNELL (US) | 2020-12-23 | — | — | EP | disclosed |
| US-8999981-B2 | 3-amido-pyrrolo[3,4-C]pyrazole-5(1H, 4H,6H) carbaldehyde derivatives | PFIZER INC. (US) | 2015-04-07 | — | — | US | disclosed |
| US-20120108588-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER, INC. (US) | 2012-05-03 | — | — | US | disclosed |
| US-8114871-B2 | 3-amido-pyrrolo[3,4-C]pyrazole-5(1H,4H,6H) carbaldehyde derivatives | PFIZER INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20100249128-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES | PFIZER INC. | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249128-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H,4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, PYCR1 | POLB 3330/4885FKBP1A 660/4885ALDH1A1 367/4885 |
| US-20120108588-A1 | NOVEL 3-AMIDO-PYRROLO[3,4-C]PYRAZOLE-5(1H, 4H,6H) CARBALDEHYDE DERIVATIVES | INSR, IAPP, PYCR1 | POLB 3330/4885FKBP1A 660/4885ALDH1A1 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.