Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 19/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6384644 | 0.89 | MMP1 (0.46) | MMP1ADAM17 | |
| SCHEMBL27527617 | 0.82 | ALOX5AP (0.40) | ALOX5APMMP1ADAM17 | |
| SCHEMBL6380696 | 0.80 | MMP1 (0.59) | MMP1ADAM17MMP13 | |
| SCHEMBL5757157 | 0.80 | MMP1 (0.61) | MMP1ADAM17 | |
| SCHEMBL6386163 | 0.76 | MMP1 (0.53) | MMP1ADAM17MMP13 | |
| SCHEMBL5760182 | 0.74 | ADAM17 (0.48) | MMP1ADAM17MMP13 | |
| SCHEMBL8521422 | 0.73 | AKR1B1 (0.40) | ALOX5APMMP1ADAM17MMP13 | |
| SCHEMBL5760409 | 0.73 | MMP1 (0.48) | MMP1ADAM17 | |
| SCHEMBL27505029 | 0.72 | MMP1 (0.47) | MMP1ADAM17MMP13 | |
| SCHEMBL27538251 | 0.72 | NPSR1 (0.41) | ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215549-A1 | TACE inhibitors | MCCLURE KIM F | 2005-09-29 | — | — | US | disclosed |
| US-20030181441-A1 | TACE INHIBITORS | McCLURE Kim (US) | 2003-09-25 | — | — | US | disclosed |
| EP-0960098-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1998034918-A1 | ARYLSULFONYL HYDROXAMIC ACID DERIVATIVES | PFIZER INC. (US) | 1998-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181441-A1 | TACE INHIBITORS | ADAMTS5, ADAMTS1, MMP2 | ALOX5AP 4415/4885MMP1 18/4885ADAM17 22/4885 |
| US-20050215549-A1 | TACE inhibitors | ADAMTS5, ADAMTS1, MMP2 | ALOX5AP 4534/4885MMP1 15/4885ADAM17 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.