Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 4/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.66 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.60 |
| ▸ | FAAH | O00519 | 2/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24277478 | 1.00 | SPR (0.74) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL29804259 | 0.91 | HDAC8 (0.77) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL20168582 | 0.91 | HDAC8 (0.77) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL20168578 | 0.91 | HDAC8 (0.77) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL15145420 | 0.87 | SPR (0.77) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL7706652 | 0.86 | SPR (0.68) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL15145410 | 0.85 | HDAC8 (0.68) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL12720784 | 0.85 | SPR (1.00) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL1132343 | 0.85 | CTSC (0.76) | SPRHDAC8KDM4EALDH1A1NPSR1 | |
| SCHEMBL5121693 | 0.83 | NPSR1 (0.67) | SPRHDAC8KDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365540-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-11-16 | — | — | US | disclosed |
| US-20230365540-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-11-16 | — | — | US | disclosed |
| EP-4211114-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | The Regents of the University of California (US) | 2023-07-19 | — | — | EP | disclosed |
| WO-2022056068-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | THE REGENTS OF THE UNIVERSITY OFCALIFORNIA (US) | 2022-03-17 | — | — | WO | disclosed |
| WO-2022056068-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | THE REGENTS OF THE UNIVERSITY OFCALIFORNIA (US) | 2022-03-17 | — | — | WO | disclosed |
| US-20050019841-A1 | Modulation of signaling pathways | ARBOR VITA CORPORATION (US) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365540-A1 | SMALL MOLECULE INHIBITORS OF ENPP1 | ENPP1, ENPP2, ENPP3 | SPR 4433/4885HDAC8 2715/4885KDM4E 4070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.