Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10699043 | 0.85 | CA1 (0.48) | MAPK1HSD17B10ALDH1A1LMNARECQL | |
| SCHEMBL14600392 | 0.85 | CA1 (0.53) | MAPK1HSD17B10ALOX15ALDH1A1LMNA | |
| SCHEMBL6400649 | 0.83 | POLB (0.44) | MAPK1ALDH1A1LMNATDP1MAPT | |
| SCHEMBL6153059 | 0.83 | KMT2A (0.48) | MAPK1ALDH1A1LMNACA1CA2 | |
| SCHEMBL5183124 | 0.83 | SRC (0.51) | MAPK1HSD17B10ALOX15ALDH1A1TDP1 | |
| SCHEMBL14632299 | 0.82 | EPHX2 (0.44) | ALDH1A1LMNACA1CA2MAPT | |
| SCHEMBL6613084 | 0.81 | CES2 (0.53) | MAPK1HSD17B10ALOX15ALDH1A1LMNA | |
| SCHEMBL10696877 | 0.81 | PLK1 (0.45) | MAPK1ALOX15ALDH1A1LMNAMAPT | |
| SCHEMBL6804828 | 0.80 | MAOB (0.57) | ALDH1A1MAPTRAB9AHDAC3HDAC1 | |
| SCHEMBL757101 | 0.76 | CES2 (0.61) | MAPK1HSD17B10ALOX15ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004735-A1 | Method for inhibiting the replication of herpes viruses | AICURIS GMBH & CO. KG (DE) | 2007-01-04 | — | — | US | disclosed |
| US-20050059658-A1 | Pyridazinone | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-17 | — | — | US | disclosed |
| EP-1404657-A1 | PYRIDAZINONE | Bayer HealthCare AG (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003002541-A1 | PYRIDAZINONE | BAYER HEALTHCARE AG (DE) | 2003-01-09 | — | — | WO | disclosed |
| EP-0252639-A1 | Leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1988-01-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059658-A1 | Pyridazinone | TYMP, TPMT, PDXK | MAPK1 1601/4885HSD17B10 3395/4885ALOX15 3032/4885 |
| US-20070004735-A1 | Method for inhibiting the replication of herpes viruses | RPL35, PCNA, MCM5 | MAPK1 2447/4885HSD17B10 3428/4885ALOX15 4172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.