Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14439688 | 0.88 | POLB (0.56) | PKMMEN1KMT2AHTTMAPT | |
| SCHEMBL29732951 | 0.83 | RAB9A (0.60) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL24553602 | 0.83 | RAB9A (0.60) | MEN1KMT2AHTTMAPTALDH1A1 | |
| SCHEMBL3874703 | 0.81 | RAB9A (0.57) | PKMCYP2D6MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11338146 | 0.81 | LMNA (0.72) | MEN1KMT2ACYP1A2CYP2D6HTT | |
| SCHEMBL11743461 | 0.81 | KDM4E (0.58) | MEN1KMT2ACYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL2900203 | 0.81 | MEN1 (0.66) | PKMMEN1KMT2ACYP1A2CYP2D6 | |
| SCHEMBL4718416 | 0.80 | RPS6KA5 (0.49) | PKMMEN1KMT2ACYP2D6HTT | |
| Iodide SCHEMBL2892303 | 0.80 | MEN1 (0.64) | PKMMEN1KMT2ACYP1A2CYP2D6 | |
| Iodide SCHEMBL2900263 | 0.80 | MEN1 (0.64) | PKMMEN1KMT2ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107416-A1 | 17-hydroxy 4-aza androstan -3-ones as androgen receptor modulators | MERCK SHARP & DOHME CORP. | 2005-05-19 | — | — | US | claimed |
| US-20070203134-A1 | Benzimidazole Acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-08-30 | — | — | US | disclosed |
| US-20070203134-A1 | Benzimidazole Acetonitriles | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-08-30 | — | — | US | disclosed |
| US-20050153978-A1 | Medicaments | GLAXO GROUP LIMITED (GB) | 2005-07-14 | — | — | US | disclosed |
| EP-1487441-A2 | BENZIMIDAZOLES AND THEIR USE AS MITOGEN-ACTIVATED- AND RHO-KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080125-A2 | BENZIMIDAZOLES AND THEIR USE AS MITOGEN-ACTIVATED- AND RHO-KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107416-A1 | 17-hydroxy 4-aza androstan -3-ones as androgen receptor modulators | SHBG, CYP19A1, NR5A1 | PKM 3506/4885MEN1 4077/4885KMT2A 1282/4885 |
| US-20070203134-A1 | Benzimidazole Acetonitriles | PKD1, GPR119, CCNI | PKM 215/4885MEN1 1391/4885KMT2A 2769/4885 |
| US-20050153978-A1 | Medicaments | GRK1, ROCK1, GRK7 | PKM 1825/4885MEN1 261/4885KMT2A 3764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.