Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.49 |
| ▸ | MAPT | P10636 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14257256 | 0.78 | TRPV1 (0.47) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL30544195 | 0.77 | KDM4E (0.67) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL2315592 | 0.77 | KDM4E (0.67) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL4850418 | 0.77 | ALDH1A1 (0.56) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2319974 | 0.76 | KDM4E (0.65) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL6403118 | 0.74 | MEN1 (0.54) | ALDH1A1KDM4EKMT2ASMN1; SMN2LMNA | |
| SCHEMBL5660097 | 0.73 | TRPV1 (0.71) | TRPV1 | |
| SCHEMBL6402994 | 0.73 | TRPM5 (0.39) | — | |
| SCHEMBL6402372 | 0.73 | TRPM5 (0.39) | — | |
| SCHEMBL30114438 | 0.72 | TRPV1 (0.64) | ALDH1A1MAPTKDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171195-A1 | P2X7 antagonists for treating neuropathic pain | ABBOTT LABORATORIES | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171195-A1 | P2X7 antagonists for treating neuropathic pain | P2RX3, P2RX7, P2RX1 | ALDH1A1 1730/4885MAPT 3662/4885KDM4E 3084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.