⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221480 | 0.76 | TSHR (0.32) | — | |
| SCHEMBL4753188 | 0.68 | RAB9A (0.32) | — | |
| SCHEMBL5083188 | 0.65 | DRD2 (0.47) | — | |
| SCHEMBL13415331 | 0.63 | DRD2 (0.46) | — | |
| SCHEMBL8602360 | 0.62 | KDM4E (0.42) | — | |
| SCHEMBL13326543 | 0.61 | — | — | |
| SCHEMBL13397234 | 0.61 | TSHR (0.32) | — | |
| SCHEMBL18723459 | 0.61 | TSHR (0.32) | — | |
| SCHEMBL23937906 | 0.59 | MEN1 (0.36) | — | |
| SCHEMBL20780055 | 0.57 | SIGMAR1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6855730-B2 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040024010-A1 | 3-methylidenyl-2-indolinone modulators of protein kinase | SUGEN, INC. | 2004-02-05 | — | — | US | disclosed |
| US-6531502-B1 | Antitumor | SUGEN, INC. | 2003-03-11 | — | — | US | disclosed |