SCHEMBL6407916

SCHEMBL6407916

Nc1ccc(CCl)cc1CCl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.41
KDM4E B2RXH2 1/20 0.37
MEN1 O00255 1/20 0.37
POLB P06746 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
TSHR P16473 4/20 0.35
ALDH1A1 P00352 4/20 0.33
CDC25B P30305 1/20 0.32
CASP6 P55212 1/20 0.32
RCE1 Q9Y256 1/20 0.32
ALOX15 P16050 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
SKP2 Q13309 1/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
TTR P02766 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27656591 0.86 CYP3A4 (0.39) CYP3A4KDM4EMEN1POLBGAA
Hydrochloric Acid SCHEMBL6476682 0.83 ATP4A (0.39) CYP3A4POLBGAAMAPTRAB9A
SCHEMBL22688527 0.78 CYP3A4 (0.38) CYP3A4KDM4EMEN1POLBGAA
SCHEMBL27463746 0.78 CYP3A4 (0.39) CYP3A4MEN1POLBGAAMAPT
SCHEMBL3700915 0.77 CA1 (0.34) KMT2ATSHRCA1CA2TTR
SCHEMBL29587349 0.77 CA1 (0.34) KMT2ATSHRCA1CA2TTR
Hydrochloric Acid SCHEMBL6475655 0.77 SKP2 (0.59) RAB9ASMN1; SMN2SKP2CA1CA2
SCHEMBL5293147 0.74 ALDH1A1 (0.50) GAAALDH1A1
SCHEMBL29902445 0.74 KDM4E (0.41) KDM4EMEN1POLBMAPTKMT2A
SCHEMBL9508003 0.74 TDP1 (0.52) CYP3A4POLBMAPTRAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6921770-B2 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2005-07-26 US disclosed
EP-1311160-A4 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INST SCI & TECH (KR) 2004-04-21 EP disclosed
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-10-30 US disclosed
EP-1311160-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2003-05-21 EP disclosed
WO-2002013611-A1 2-PHENYLIMINOTHIAZOLINES, THEIR PREPARATION METHOD AND ANTI-RICE BLAST AGENT CONTAINING THE SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2002-02-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030203950-A1 2-Phenyliminothiazolines, their preparation method and anti-rice blast agent containing the same TYR, SYPL1, SSBP1 CYP3A4 3969/4885KDM4E 4273/4885MEN1 131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.