Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.31 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.30 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6412550 | 0.87 | PRMT5 (0.34) | PRMT5WDR77PDE2ACACNA1H | |
| SCHEMBL6413460 | 0.87 | PRMT5 (0.32) | PRMT5WDR77DPP4 | |
| SCHEMBL6411741 | 0.80 | FNTA (0.34) | PRMT5WDR77DAOGPR52 | |
| SCHEMBL6408970 | 0.77 | PRMT5 (0.31) | PRMT5WDR77 | |
| SCHEMBL7166984 | 0.75 | PRMT5 (0.41) | PRMT5WDR77RETDAODPP4 | |
| SCHEMBL7165817 | 0.75 | FNTA (0.40) | PRMT5WDR77RETPDE2ACACNA1H | |
| SCHEMBL7566917 | 0.74 | BCAT2 (0.32) | PRMT5WDR77CACNA1HGPR52 | |
| SCHEMBL6409378 | 0.74 | HTR1A (0.35) | — | |
| SCHEMBL7648195 | 0.72 | GPR119 (0.43) | RET | |
| SCHEMBL6410691 | 0.71 | CACNA1H (0.30) | CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |