Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | RORA | P35398 | 1/20 | 0.64 |
| ▸ | RORC | P51449 | 1/20 | 0.64 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.64 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.54 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.53 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | TYMS | P04818 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31110643 | 0.86 | TSHR (0.74) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL812673 | 0.86 | TSHR (0.74) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL9478942 | 0.84 | TSHR (0.71) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL3261087 | 0.84 | TSHR (0.71) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL16785737 | 0.84 | TSHR (0.67) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL5046687 | 0.82 | TSHR (0.64) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL3622402 | 0.81 | FABP4 (0.58) | ALDH1A1HTTMEN1KMT2ABRD4 | |
| SCHEMBL15762086 | 0.80 | TSHR (1.00) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL12793716 | 0.80 | ALDH1A1 (0.65) | TSHRPGRRORARORCNR1H2 | |
| SCHEMBL8752480 | 0.80 | PGR (0.74) | TSHRPGRRORARORCNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581511-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058736-A1 | CCR8 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2004-07-15 | — | — | WO | disclosed |