Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6403192 | 0.87 | QDPR (0.47) | DRD3MTNR1B | |
| SCHEMBL6404493 | 0.83 | CYP2D6 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2DRD2 | |
| SCHEMBL6403231 | 0.82 | MTNR1B (0.42) | DRD3MTNR1B | |
| SCHEMBL6413104 | 0.79 | CNR1 (0.44) | MTNR1B | |
| SCHEMBL6405961 | 0.79 | HPGD (0.46) | MTNR1B | |
| SCHEMBL6408461 | 0.78 | NAPEPLD (0.38) | MTNR1B | |
| SCHEMBL6405842 | 0.78 | PROKR1 (0.50) | MTNR1B | |
| SCHEMBL6001636 | 0.76 | DRD2 (0.52) | SLC6A3DRD2DRD3MTNR1B | |
| SCHEMBL6405341 | 0.76 | MTNR1B (0.50) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL6406991 | 0.76 | MTNR1B (0.47) | DRD2MTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288304-A1 | Tetrahydronaphthylpiperazines as 5HT1B antagonists, inverse agonists and partial agonists | PFIZER INC | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288304-A1 | Tetrahydronaphthylpiperazines as 5HT1B antagonists, inverse agonists and partial agonists | HTR1A, HTR1B, HTR1D | SLC6A2 212/4885SLC6A4 125/4885SLC6A3 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.