Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407197 | 0.85 | TOP2A (0.46) | HKDC1TOP2ATDP2 | |
| SCHEMBL6408056 | 0.78 | TOP2A (0.36) | MAOAAPPACHEHPGDMAPT | |
| SCHEMBL6407858 | 0.78 | TDP2 (0.39) | KMT2AHKDC1TOP2ATDP1TDP2 | |
| SCHEMBL6863937 | 0.73 | TOP2A (0.50) | MAOAHPGDMAPTLMNAMAPK1 | |
| SCHEMBL6866894 | 0.66 | KMT2A (0.41) | MAOAHPGDMAPTLMNAMAPK1 | |
| SCHEMBL6408548 | 0.64 | TOP2A (0.53) | MAOAHPGDMAPTLMNAMAPK1 | |
| SCHEMBL30511844 | 0.64 | MTNR1A (0.64) | HPGDLMNAMAPK1ALDH1A1F2 | |
| SCHEMBL1059319 | 0.63 | ALDH1A1 (0.44) | HPGDMAPK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7043300 | 0.63 | TOP2A (0.52) | KMT2ATOP2ATDP1TDP2 | |
| SCHEMBL6866024 | 0.63 | TDP2 (0.51) | MAPTLMNAMAPK1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202993-B1 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LAFON LABOR (FR) | 2005-10-19 | — | — | EP | claimed |
| US-6809096-B1 | SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS | LABORATOIRE L. LAFON (FR) | 2004-10-26 | — | — | US | claimed |
| US-6809096-B1 | SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS | LABORATOIRE L. LAFON (FR) | 2004-10-26 | — | — | US | disclosed |