Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410042 | 0.85 | GPR119 (0.40) | HPGDSMN1; SMN2GPR119CCNB2CDK1 | |
| SCHEMBL6410959 | 0.82 | GAA (0.36) | HPGDSMN1; SMN2MAPK1LMNAKMT2A | |
| SCHEMBL6415785 | 0.77 | HTR1A (0.46) | — | |
| SCHEMBL6410053 | 0.77 | MGLL (0.42) | HPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL2400831 | 0.77 | HPGD (0.39) | HPGDSMN1; SMN2CCNB2CDK1CCNB1 | |
| SCHEMBL6416363 | 0.77 | KDM4E (0.46) | SMN1; SMN2MAPK1KMT2AMEN1 | |
| SCHEMBL6415762 | 0.75 | KMT2A (0.64) | SMN1; SMN2LMNAKMT2AMEN1CYP3A4 | |
| SCHEMBL6409627 | 0.75 | HPGD (0.40) | HPGDEPHX2USP2ALDH1A1 | |
| SCHEMBL6418195 | 0.74 | POLB (0.55) | HPGDSMN1; SMN2MAPK1KMT2AMEN1 | |
| SCHEMBL6409750 | 0.73 | HPGD (0.47) | HPGDSMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |