Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.63 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6407850 | 0.77 | PARP1 (1.00) | PARP1 | |
| Hydrochloric Acid SCHEMBL6408278 | 0.77 | PARP1 (0.66) | PARP1PARP2MEN1KMT2A | |
| SCHEMBL8958326 | 0.77 | SIGMAR1 (0.67) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL8109444 | 0.76 | SIGMAR1 (0.58) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL6411446 | 0.75 | PARP1 (0.62) | PARP1PARP2 | |
| SCHEMBL14981676 | 0.75 | PARP1 (1.00) | PARP1PARP2CHRNA7 | |
| SCHEMBL9521523 | 0.75 | SIGMAR1 (1.00) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL6408260 | 0.74 | PARP1 (1.00) | PARP1SIGMAR1CYP1A2CYP3A4TSHR | |
| SCHEMBL8109930 | 0.73 | HTR1A (0.69) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL6405478 | 0.72 | PARP1 (0.54) | PARP1PARP2MEN1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171101-A1 | Phenanthridinones as parp inhibitors | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171101-A1 | Phenanthridinones as parp inhibitors | PARP1, PARP11, PARP2 | PARP1 1/4885PARP2 3/4885SIGMAR1 1351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.