Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.67 |
| ▸ | HTR1A | P08908 | 6/20 | 0.61 |
| ▸ | HTR2C | P28335 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109930 | 0.92 | HTR1A (0.69) | SIGMAR1HTR1AHTR2CMEN1TP53 | |
| SCHEMBL8110695 | 0.86 | SIGMAR1 (0.67) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL8948027 | 0.84 | HTR1A (0.57) | SIGMAR1HTR1AHTR2CCYP1A2CYP3A4 | |
| SCHEMBL8947912 | 0.83 | HTR1A (0.85) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL8117008 | 0.80 | SIGMAR1 (1.00) | SIGMAR1HTR1AHTR2CMEN1TP53 | |
| SCHEMBL8109444 | 0.80 | SIGMAR1 (0.58) | SIGMAR1MEN1TP53CYP1A2CYP3A4 | |
| SCHEMBL8948040 | 0.80 | HTR1A (0.61) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL8948002 | 0.79 | HTR1A (0.87) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL7756727 | 0.79 | HTR1A (0.64) | HTR1AHTR2C | |
| SCHEMBL8116065 | 0.78 | HTR1A (0.67) | SIGMAR1HTR1AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534511-A | AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |