Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 6/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830038 | 0.80 | CRBN (0.65) | CRBNDDB1ALDH1A1TSHRKDM4E | |
| SCHEMBL29787379 | 0.77 | CRBN (0.71) | CRBNPOLBDDB1ALDH1A1TSHR | |
| SCHEMBL2563426 | 0.77 | CRBN (0.71) | CRBNPOLBDDB1ALDH1A1TSHR | |
| SCHEMBL21517777 | 0.75 | CRBN (0.33) | CRBNDDB1 | |
| SCHEMBL20298293 | 0.73 | CRBN (0.32) | CRBN | |
| SCHEMBL8473403 | 0.69 | ALDH1A1 (0.46) | CRBNPOLBALDH1A1TSHRKDM4E | |
| SCHEMBL28328116 | 0.69 | CRBN (0.35) | CRBNPOLBHSD17B10MAPTKMT2A | |
| SCHEMBL8470423 | 0.69 | CRBN (0.41) | CRBNPDE3BPDE3AALDH1A1KDM4E | |
| SCHEMBL8474128 | 0.69 | CRBN (0.43) | CRBNPDE3BPDE3ALMNADDB1 | |
| SCHEMBL746783 | 0.68 | CRBN (0.66) | CRBNDDB1KDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534696-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004011448-A1 | THERAPEUTIC COMPOUNDS FOR TREATING DYSLIPIDEMIC CONDITIONS | MERCK & CO., INC. (US) | 2004-02-05 | — | — | WO | disclosed |