Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 2/20 | 0.58 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | NSD2 | O96028 | 3/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.38 |
| ▸ | BRD7 | Q9NPI1 | 3/20 | 0.38 |
| ▸ | TOP1 | P11387 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599222 | 0.74 | S100A4 (1.00) | S100A4CDC25BNSD2TDP2ALDH1A1 | |
| SCHEMBL3555324 | 0.72 | S100A4 (0.51) | S100A4CDC25BKDM4EMAPTMAOA | |
| SCHEMBL11358184 | 0.69 | S100A4 (0.59) | S100A4CDC25BPOLBKDM4EALDH1A1 | |
| SCHEMBL28289103 | 0.69 | S100A4 (0.59) | S100A4CDC25BNSD2TDP2POLB | |
| SCHEMBL1893435 | 0.67 | CA9 (0.50) | S100A4TDP1KDM4EALDH1A1MAPT | |
| SCHEMBL3546351 | 0.67 | S100A4 (0.55) | S100A4CDC25BALDH1A1HPGDIDO1 | |
| SCHEMBL22310713 | 0.66 | USP8 (0.43) | NSD2TXNRD1IDO1G6PDDNMT1 | |
| SCHEMBL17276010 | 0.66 | BRD9 (0.56) | BRD9BRD7POLBTDP1NNMT | |
| SCHEMBL31438401 | 0.66 | BRD9 (0.56) | BRD9BRD7POLBTDP1NNMT | |
| SCHEMBL24834476 | 0.65 | ALDH1A1 (0.50) | BRD9BRD7POLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202993-B1 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LAFON LABOR (FR) | 2005-10-19 | — | — | EP | disclosed |
| US-6809096-B1 | SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS | LABORATOIRE L. LAFON (FR) | 2004-10-26 | — | — | US | disclosed |
| EP-1202992-B1 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | CEPHALON FRANCE (FR) | 2004-09-15 | — | — | EP | disclosed |
| US-6515127-B1 | The invention concerns a method for preparing quinoline-5,8-diones of formula (I) light-induced oxygenation of a 8-hydroxyquinoline. and intermediates | LABORATOIRE L. LAFON (FR) | 2003-02-04 | — | — | US | disclosed |
| EP-1202972-A2 | METHOD FOR PREPARING QUINOLINE-5,8-DIONES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| EP-1202992-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| EP-1202993-A2 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012597-A2 | METHOD FOR PREPARING QUINOLINE-5,8-DIONES | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |
| WO-2001012632-A2 | PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |
| WO-2001012631-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |