SCHEMBL641315

SCHEMBL641315

O=Nc1ccc(N(CCO)CC(O)COCCO)cc1

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.33
TP53 P04637 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
HIF1A Q16665 1/20 0.33
HSD17B10 Q99714 1/20 0.33
GAA P10253 1/20 0.32
LMNA P02545 1/20 0.31
NR1H2 P55055 1/20 0.30
NR1H3 Q13133 1/20 0.30
PSMD14 O00487 1/20 0.30
NPC1 O15118 1/20 0.30
MITF O75030 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL144082 0.88 ALDH1A1 (0.37) ALDH1A1TP53TSHRMAPK1HIF1A
Hydrochloric Acid SCHEMBL9015914 0.87 ALDH1A1 (0.36) ALDH1A1TP53TSHRMAPK1HIF1A
SCHEMBL9437766 0.86 ALDH1A1 (0.40) ALDH1A1TP53TSHRMAPK1HIF1A
SCHEMBL145415 0.80 TSHR (0.38) ALDH1A1TP53TSHRMAPK1HIF1A
Hydrochloric Acid SCHEMBL9015906 0.79 TSHR (0.37) ALDH1A1TP53TSHRMAPK1HIF1A
SCHEMBL147073 0.76 ALDH1A1 (0.48) ALDH1A1TP53TSHRMAPK1HIF1A
Hydrochloric Acid SCHEMBL6254389 0.75 ALDH1A1 (0.47) ALDH1A1TP53TSHRMAPK1HIF1A
SCHEMBL13558573 0.75 POLB (0.35) ALDH1A1HSD17B10MAPT
SCHEMBL10025577 0.70 KMT2A (0.51) ALDH1A1TP53TSHRMAPK1HIF1A
SCHEMBL145463 0.70 ALDH1A1 (0.38) ALDH1A1TP53TSHRMAPK1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 US claimed
US-5286362-A Reducible substance is enzymatically reduced and oxidized at the electrode; substance formed by oxidation is different from the reducible substance used initially BOEHRINGER MANNHEIM GMBH (DE) 1994-02-15 US claimed
EP-4481375-A2 DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTE DIAGNOSTIC TEST ELEMENTS, AS WELL AS METHODS OF USING THE SAME F. Hoffmann-La Roche AG (CH) 2024-12-25 EP disclosed
EP-3523639-B1 DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTE DIAGNOSTIC TEST ELEMENTS, AS WELL AS METHODS OF USING THE SAME HOFFMANN LA ROCHE (CH) 2024-12-18 EP disclosed
US-20240327892-A1 DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTE DIAGNOSTIC TEST ELEMENTS, AS WELL AS METHODS OF USING THE SAME ROCHE DIABETES CARE, INC. 2024-10-03 US disclosed
US-12024735-B2 Detection reagents and electrode arrangements for multi-analyte diagnostic test elements, as well as methods of using the same ROCHE DIABETES CARE, INC. (US) 2024-07-02 US disclosed
US-11851685-B2 Zwitterion buffer containing compositions and uses in electroanalytical devices and methods ROCHE DIABETES CARE, INC. (US) 2023-12-26 US disclosed
EP-4152003-A1 SYSTEMS AND METHODS FOR MULTIPLE ANALYTE ANALYSIS Roche Diabetes Care GmbH (DE) 2023-03-22 EP disclosed
EP-3757574-B1 SYSTEMS AND METHODS FOR MULTIPLE ANALYTE ANALYSIS ROCHE DIABETES CARE GMBH (DE) 2022-12-07 EP disclosed
US-20220275348-A1 ZWITTERION BUFFER CONTAINING COMPOSITIONS AND USES IN ELECTROANALYTICAL DEVICES AND METHODS ROCHE DIABETES CARE, INC. 2022-09-01 US disclosed
US-20220098636-A1 DETECTION REAGENTS AND ELECTRODE ARRANGEMENTS FOR MULTI-ANALYTE DIAGNOSTIC TEST ELEMENTS, AS WELL AS METHODS OF USING THE SAME ROCHE DIABETES CARE, INC. (US) 2022-03-31 US disclosed
EP-2265726-A1 BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY Roche Diagnostics GmbH (DE) 2010-12-29 EP disclosed
US-7829023-B2 Easy dosing; robust, flexible; allows air to escape as fluid enters sampling chamber; accurate, fast; reduced sample size; blood glucose monitoring ROCHE DIAGNOSTICS OPERATIONS, INC. (US) 2010-11-09 US disclosed
WO-2009118157-A1 BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY ROCHE DIAGNOSTICS GMBH (DE) 2009-10-01 WO disclosed
US-20090246808-A1 BIOSENSOR WITH IMPROVED ANALYTE SPECIFICITY ROCHE DIABETES CARE, INC. 2009-10-01 US disclosed
US-20050013731-A1 Test strip with slot vent opening ROCHE DIABETES CARE, INC. 2005-01-20 US disclosed
EP-0441222-B1 Process and electrode system for determining an analyte or an oxidoreductase as well as suitable compounds BOEHRINGER MANNHEIM GMBH (DE) 1996-12-18 EP disclosed
US-5286362-A Reducible substance is enzymatically reduced and oxidized at the electrode; substance formed by oxidation is different from the reducible substance used initially BOEHRINGER MANNHEIM GMBH (DE) 1994-02-15 US disclosed
US-5122244-A Having a reducible nitroso or oxime compound to transfer electrons leading to a signal and form an aromatic amine oxidizable to a compound different from the original; low voltage BOEHRINGER MANNHEIM GMBH (DE) 1992-06-16 US disclosed
EP-0441222-A2 Process and electrode system for determining an analyte or an oxidoreductase as well as suitable compounds Roche Diagnostics GmbH (DE) 1991-08-14 EP disclosed