Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | TACR2 | P21452 | 4/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6408359 | 0.93 | ALDH1A1 (0.41) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL6416011 | 0.91 | ROCK2 (0.44) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL6409321 | 0.91 | UTS2R (0.42) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL6410274 | 0.91 | ALDH1A1 (0.38) | MMP1MMP13CCR5ALDH1A1LMNA | |
| SCHEMBL6409348 | 0.90 | ROCK2 (0.40) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL6408529 | 0.89 | CCR5 (0.40) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL6410157 | 0.89 | CACNA1G (0.42) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL6415166 | 0.88 | ALDH1A1 (0.40) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL6413430 | 0.87 | CCR5 (0.41) | MMP1MMP13MMP9ADAM17CCR5 | |
| SCHEMBL5255921 | 0.87 | CCR5 (0.38) | CCR5ALDH1A1LMNATACR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | MMP1 873/4885MMP13 1146/4885MMP9 884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.