Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6409182 | 0.93 | HPGD (0.35) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL6408359 | 0.93 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPK1ALOX15CCR5 | |
| SCHEMBL6416011 | 0.91 | ROCK2 (0.44) | ALDH1A1LMNAMAPK1ALOX15ROCK2 | |
| SCHEMBL6414389 | 0.91 | CCR5 (0.37) | ALDH1A1CCR2CCR5TSHRUTS2R | |
| SCHEMBL6415595 | 0.91 | MMP1 (0.40) | ALDH1A1LMNAMAPK1ALOX15ROCK2 | |
| SCHEMBL6408826 | 0.90 | MEN1 (0.43) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL6409321 | 0.90 | UTS2R (0.42) | ALDH1A1LMNAKMT2AMAPK1CCR5 | |
| SCHEMBL6435174 | 0.90 | MEN1 (0.40) | ALDH1A1MEN1KMT2AMAPK1POLB | |
| Hydrochloric Acid SCHEMBL6408823 | 0.89 | MEN1 (0.43) | ALDH1A1LMNAMEN1KMT2AMAPK1 | |
| SCHEMBL6410157 | 0.89 | CACNA1G (0.42) | ALDH1A1LMNAMAPK1ALOX15CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | ALDH1A1 869/4885LMNA 3107/4885MEN1 4007/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.