Sugi Predict

Sugi Predict / Compounds / SCHEMBL641759

SCHEMBL641759

SCHEMBL641759

O=C(CBr)c1ccc(Cl)cc1Cl

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.69
▸ MAPK1 P28482 1/20 0.69
▸ HIF1A Q16665 1/20 0.69
▸ ERCC5 P28715 2/20 0.61
▸ FEN1 P39748 2/20 0.61
▸ TSHR P16473 1/20 0.59
▸ CASP1 P29466 1/20 0.59
▸ SMN1; SMN2 Q16637 1/20 0.59
▸ KDM4E B2RXH2 1/20 0.56
▸ MAPT P10636 1/20 0.56
▸ GSK3B P49841 1/20 0.53
▸ POLB P06746 3/20 0.49
▸ L3MBTL1 Q9Y468 2/20 0.49
▸ THRB P10828 1/20 0.49
▸ RECQL P46063 1/20 0.49
▸ TDP1 Q9NUW8 1/20 0.49
▸ CYP3A4 P08684 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ SRD5A2 P31213 1/20 0.47
▸ AGTR1 P30556 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29859075 1.00 ALDH1A1 (0.69) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL2256259 0.85 ALDH1A1 (0.65) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL29391618 0.84 ERCC5 (0.61) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL404490 0.84 ERCC5 (0.61) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL10159191 0.82 GSK3B (0.52) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL6579360 0.82 PTPN1 (0.48) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL30356509 0.82 GSK3B (0.48) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL7779200 0.82 GSK3B (0.52) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL30702134 0.82 GSK3B (0.52) ALDH1A1MAPK1HIF1AERCC5FEN1
SCHEMBL6516476 0.82 GSK3B (0.48) ALDH1A1MAPK1HIF1AERCC5FEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 394 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109879862-A A kind of synthesis technology of propiconazole 长沙鑫本药业有限公司 2019-06-14 — — CN claimed
US-20140235863-A1 SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2014-08-21 — — US claimed
WO-2012164572-A1 SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2012-12-06 — — WO claimed
US-20110288315-A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUND DAISO CO., LTD. (JP) 2011-11-24 — — US claimed
EP-2325178-A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUND DAISO CO., LTD. (JP) 2011-05-25 — — EP claimed
EP-1243581-B1 Pyridinium compounds useful for the treatment of AGE-related diseases TORRENT PHARMACEUTICALS LTD (IN) 2005-07-13 — — EP claimed
EP-0300413-B1 MICROBICIDAL AGENTS CIBA-GEIGY AG (CH) 1993-09-01 — — EP claimed
US-4940799-A Preparation of the diastereomeric mixture 2R,4S-1-[2-(2,4-dichlorophenyl)-4-n-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole CIBA-GEIGY CORPORATION (US) 1990-07-10 — — US claimed
EP-0300413-A2 Microbicidal agents CIBA-GEIGY AG (CH) 1989-01-25 — — EP claimed
EP-3863634-B1 LEVOKETOCONAZOLE FOR TREATMENT OF CONGENITAL ADRENAL HYPERPLASIA STRONGBRIDGE DUBLIN LTD (IE) 2026-04-08 — — EP disclosed
US-12545666-B2 Itraconazole analogs and use thereof THE JOHNS HOPKINS UNIVERSITY (US) 2026-02-10 — — US disclosed
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors GENZYME CORPORATION 2025-12-23 — — US disclosed
US-12201632-B2 Levoketoconazole for treatment of congenital adrenal hyperplasia and primary aldosteronism STRONGBRIDGE DUBLIN LIMITED (IE) 2025-01-21 — — US disclosed
US-20240360111-A1 ITRACONAZOLE ANALOGS AND USE THEREOF THE JOHNS HOPKINS UNIVERSITY 2024-10-31 — — US disclosed
EP-0000017-A1 1-(2-Phenylethyl)-triazolium salts, their preparation and their use as fungicides BAYER AG (DE) 1978-12-20 — — EP disclosed
US-4127660-A ANTIULCER JOHN WYETH & BROTHER LIMITED (GB) 1978-11-28 — — US disclosed
US-4120869-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1978-10-17 — — US disclosed
US-4101666-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1978-07-18 — — US disclosed
US-4101665-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1978-07-18 — — US disclosed
US-3936470-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1976-02-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110288315-A1 PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE COMPOUND CYP51A1, KMO, TALDO1 ALDH1A1 453/4885MAPK1 616/4885HIF1A 1833/4885
US-20240360111-A1 ITRACONAZOLE ANALOGS AND USE THEREOF CYP3A4, SHH, GLI1 ALDH1A1 428/4885MAPK1 3835/4885HIF1A 119/4885
US-20140235863-A1 SUBSTITUTED 4-ARYLTHIAZOLES AND PROCESS OF PREPARATION THEREOF TST, NQO1, FNTB ALDH1A1 111/4885MAPK1 1286/4885HIF1A 1932/4885
US-12545666-B2 Itraconazole analogs and use thereof SHH, SMO, GLI1 ALDH1A1 2379/4885MAPK1 1415/4885HIF1A 1215/4885
US-12503477-B2 Colony stimulating factor-1 receptor (CSF-1R) inhibitors CSF1R, CSF3R, IL1RN ALDH1A1 1517/4885MAPK1 397/4885HIF1A 558/4885
US-12201632-B2 Levoketoconazole for treatment of congenital adrenal hyperplasia and primary aldosteronism HSD3B1, HSD3B2, HSD11B2 ALDH1A1 314/4885MAPK1 3318/4885HIF1A 3782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.