Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 5/20 | 0.56 |
| ▸ | PRKCG | P05129 | 5/20 | 0.56 |
| ▸ | PRKCB | P05771 | 5/20 | 0.56 |
| ▸ | PRKCA | P17252 | 5/20 | 0.56 |
| ▸ | PRKCH | P24723 | 5/20 | 0.56 |
| ▸ | PRKCI | P41743 | 5/20 | 0.56 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.56 |
| ▸ | PRKCZ | Q05513 | 5/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 5/20 | 0.56 |
| ▸ | PRKACA | P17612 | 2/20 | 0.56 |
| ▸ | PRKACG | P22612 | 2/20 | 0.56 |
| ▸ | PRKACB | P22694 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29415921 | 0.88 | PRKD3 (0.62) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL78989 | 0.88 | PRKD3 (0.62) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL3959789 | 0.86 | PRKD3 (0.61) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL31615194 | 0.81 | NPC1 (0.61) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL3148480 | 0.81 | NPC1 (0.61) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL3908537 | 0.81 | PRKD3 (0.59) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL12424814 | 0.78 | KDR (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL15758300 | 0.76 | PRKCB (0.64) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2986726 | 0.75 | PRKD3 (0.53) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8086286 | 0.74 | KDR (0.58) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345946-B1 | MACROHETEROCYLIC COMPOUNDS USEFUL AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2005-08-10 | — | — | EP | disclosed |
| US-6828327-B2 | For therapy of chronic pain, neuropathic pain, epilepsy, chronic neurodegenerative conditions, dementia, Alzheimer's disease, schizophrenia, manic depression, neurotraumatic, cognitive decline and ischemia-related diseases | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-12-07 | — | — | US | disclosed |
| WO-2004083202-A1 | A PROCESS FOR THE PREPARATION OF INDOLYMALEIMIDES | SUVEN LIFE SCIENCES LIMITED (IN) | 2004-09-30 | — | — | WO | disclosed |
| EP-1345946-A1 | MACROHETEROCYLIC COMPOUNDS USEFUL AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-09-24 | — | — | EP | disclosed |
| US-20030078280-A1 | Macroheterocylic compounds useful as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-04-24 | — | — | US | disclosed |
| WO-2002046197-A1 | MACROHETEROCYLIC COMPOUNDS USEFUL AS KINASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2002-06-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078280-A1 | Macroheterocylic compounds useful as kinase inhibitors | PRKCH, MAP3K6, MAP3K2 | PRKD3 49/4885PRKCG 58/4885PRKCB 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.