Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.49 |
| ▸ | CDC25B | P30305 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28756865 | 0.85 | TSHR (0.60) | TSHRKDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL6875889 | 0.83 | TUBB4A (0.44) | NUDT1TSHRKDM4ECLEC4MTUBB4A | |
| SCHEMBL45030 | 0.82 | NR4A2 (0.63) | TSHRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL30430559 | 0.82 | NR4A2 (0.63) | TSHRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8726262 | 0.82 | HDAC1 (0.47) | NUDT1TSHRKDM4ETUBB4ATUBB | |
| SCHEMBL7425563 | 0.81 | ALDH1A1 (0.56) | TSHRALDH1A1KMT2A | |
| SCHEMBL6875364 | 0.80 | DHPS (0.46) | NUDT1KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL14823123 | 0.80 | KDM4E (0.52) | NUDT1TSHRKDM4EALDH1A1GABRA1 | |
| SCHEMBL6421132 | 0.80 | NUDT1 (0.52) | NUDT1TSHRKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7402420 | 0.80 | NUDT1 (0.50) | NUDT1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102786463-A | Method for preparing 5-acetoxyl-3-indole carboxylic acid ethyl ester | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2012-11-21 | — | — | CN | claimed |
| US-20250214969-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2025-07-03 | — | — | US | disclosed |
| US-12286653-B2 | Carboxyesterase polypeptides for amide coupling | CODEXIS, INC. (US) | 2025-04-29 | — | — | US | disclosed |
| EP-4499149-A1 | PROTEIN DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| CN-111699250-B | Carboxylesterase polypeptides for amide coupling | 科德克希思公司 | 2024-01-09 | — | — | CN | disclosed |
| WO-2023192578-A1 | PROTEIN DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| US-20210238565-A1 | CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2021-08-05 | — | — | US | disclosed |
| US-20210238565-A1 | CARBOXYESTERASE POLYPEPTIDES FOR AMIDE COUPLING | INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT | 2021-08-05 | — | — | US | disclosed |
| US-11015180-B2 | Carboxyesterase polypeptides for amide coupling | CODEXIS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| US-11015180-B2 | Carboxyesterase polypeptides for amide coupling | CODEXIS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| EP-1009738-A1 | SUBSTITUTED OXINDOLE DERIVATIVES AS PROTEIN TYROSINE KINASE AND AS PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999015500-A1 | SUBSTITUTED OXINDOLE DERIVATIVES AS PROTEIN TYROSINE KINASE AND AS PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 1999-04-01 | — | — | WO | disclosed |
| US-5380722-A | Antiarrhythmia agents | ROUSSEL-UCLAF (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5116995-A | Antipsychotic activity | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| US-5084455-A | Antiarrhythmia agents for mammals | ROUSSEL UCLAF (FR) | 1992-01-28 | — | — | US | disclosed |
| EP-0458654-A1 | Carbazole compounds | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1991-11-27 | — | — | EP | disclosed |
| US-4908367-A | Antiarrythmic agents | Uclaf, Roussel (FR) | 1990-03-13 | — | — | US | disclosed |
| US-4791109-A | Novel indole carboxamides | ROUSSEL UCLAF (FR) | 1988-12-13 | — | — | US | disclosed |
| US-4731358-A | β-carbolines and their use as tranquilizers | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-03-15 | — | — | US | disclosed |
| EP-0110814-A2 | Beta-carbolines, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250214969-A1 | PROTEIN DEGRADERS AND USES THEREOF | MDM2, CUL1, PSMG3 | NUDT1 4393/4885TSHR 3432/4885KDM4E 935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.