Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 14/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 14/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL6425854 | 0.93 | MTNR1A (0.39) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| SCHEMBL6421586 | 0.80 | MTNR1A (0.37) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| Diethylamine SCHEMBL3253500 | 0.79 | MTNR1A (0.47) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| SCHEMBL6425851 | 0.79 | MTNR1A (0.38) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| SCHEMBL6424121 | 0.77 | HTR6 (0.38) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| Diethylamine SCHEMBL3254220 | 0.75 | MTNR1A (0.47) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| SCHEMBL6437518 | 0.75 | MTNR1A (0.36) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| Dimethylamine SCHEMBL3256880 | 0.71 | MTNR1A (0.48) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| Dimethylamine SCHEMBL3256339 | 0.68 | MTNR1A (0.49) | MTNR1AMTNR1BKDM4EHSD17B10HPGD | |
| Dimethylamine SCHEMBL3250885 | 0.68 | MTNR1A (0.49) | MTNR1AMTNR1BKDM4EHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050203103-A1 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | SUVEN LIFE SCIENCES LIMITED (IN) | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203103-A1 | Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them | TPH1, HTR1A, HTR7 | MTNR1A 76/4885MTNR1B 105/4885KDM4E 3056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.