Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6420512 | 0.91 | GRIN2B (0.40) | CHRM5CHRM1CREBBPLMNATP53 | |
| SCHEMBL6422824 | 0.83 | CHRM5 (0.41) | CHRM5CHRM1LMNAGRIN2BPTGDR2 | |
| SCHEMBL6423488 | 0.81 | CHRM5 (0.39) | CHRM5CHRM1PTGDR2ALOX5CYP1A2 | |
| SCHEMBL6420101 | 0.80 | KDM4E (0.38) | KDM4EALDH1A1FAAHCYP1A2 | |
| SCHEMBL6422956 | 0.80 | CHRM5 (0.42) | CHRM5CHRM1HRH3KDM4EALDH1A1 | |
| SCHEMBL6419655 | 0.80 | PTGDR2 (0.37) | LMNAPTGDR2POLBCYP3A4RECQL | |
| SCHEMBL6422626 | 0.80 | PTGDR2 (0.37) | LMNAGRIN2BPTGDR2KDM4EALDH1A1 | |
| SCHEMBL6419627 | 0.79 | HRH3 (0.35) | PTGDR2HRH3FAAHGAA | |
| SCHEMBL6423530 | 0.78 | PTGDR2 (0.36) | GRIN2BPTGDR2ALDH1A1TDP1 | |
| SCHEMBL6420064 | 0.77 | GRIN2B (0.38) | CHRM5CHRM1GRIN2BPTGDR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |