Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6420064 | 0.90 | GRIN2B (0.38) | CHRM5CHRM1PDK2PTGDR2ALDH1A1 | |
| SCHEMBL6422956 | 0.89 | CHRM5 (0.42) | CHRM5CHRM1ALDH1A1KDM4AKDM4C | |
| SCHEMBL6423530 | 0.85 | PTGDR2 (0.36) | PDK2PTGDR2ALDH1A1P2RX7MEN1 | |
| SCHEMBL6421750 | 0.83 | CHRM5 (0.43) | CHRM5CHRM1PTGDR2ALDH1A1GAA | |
| SCHEMBL6419655 | 0.81 | PTGDR2 (0.37) | PDK2PTGDR2ALDH1A1P2RX7MEN1 | |
| SCHEMBL6423488 | 0.79 | CHRM5 (0.39) | CHRM5CHRM1PDK2PTGDR2P2RX7 | |
| SCHEMBL6420047 | 0.79 | PTGDR2 (0.37) | CHRM5CHRM1PDK2PTGDR2P2RX7 | |
| SCHEMBL6422626 | 0.79 | PTGDR2 (0.37) | PDK2PTGDR2ALDH1A1KDM4AKDM5A | |
| SCHEMBL6419627 | 0.78 | HRH3 (0.35) | PDK2PTGDR2GAAP2RX7MEN1 | |
| SCHEMBL6419294 | 0.78 | PDK2 (0.37) | CHRM5CHRM1PDK2PTGDR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |