Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6420249 | 0.90 | PTGDR2 (0.36) | PTGDR2HPGDHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6423488 | 0.83 | CHRM5 (0.39) | PTGDR2CYP1A2CYP2C9CYP2C19NAMPT | |
| SCHEMBL6422824 | 0.81 | CHRM5 (0.41) | PTGDR2ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL6422956 | 0.80 | CHRM5 (0.42) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6421750 | 0.80 | CHRM5 (0.43) | PTGDR2ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL6420064 | 0.77 | GRIN2B (0.38) | PTGDR2ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL6420518 | 0.76 | CHRM2 (0.36) | ALDH1A1LMNAPDK2 | |
| SCHEMBL6422607 | 0.75 | P2RX7 (0.43) | PTGDR2ALDH1A1MAPTPOLBPDK2 | |
| SCHEMBL6419465 | 0.75 | PDK2 (0.36) | PTGDR2NPC1RAB9AMAPTCYP2C9 | |
| SCHEMBL6419294 | 0.74 | PDK2 (0.37) | PTGDR2HSD17B10ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | disclosed |
| EP-1173438-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000063208-A1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |