Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 15/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386055 | 0.84 | TRPV4 (0.46) | TRPV4LMNAMAPTPGR | |
| SCHEMBL30307015 | 0.84 | TRPV4 (0.46) | TRPV4LMNAMAPTPGR | |
| SCHEMBL997994 | 0.82 | CASP1 (0.48) | ACLYLMNAMAPTPGR | |
| SCHEMBL7205989 | 0.81 | TRPV4 (0.42) | TRPV4LMNAMAPTPGRELANE | |
| SCHEMBL31387938 | 0.81 | TRPV4 (0.42) | TRPV4LMNAMAPTPGRELANE | |
| SCHEMBL4836069 | 0.80 | HTR2A (0.49) | TRPV4EPAS1PGR | |
| SCHEMBL5678951 | 0.80 | CASP1 (0.54) | TRPV4 | |
| SCHEMBL5682872 | 0.78 | GAA (0.53) | LMNAMAPT | |
| SCHEMBL8360769 | 0.77 | TSHR (0.41) | TRPV4EPAS1LMNAMAPTVEGFA | |
| SCHEMBL926865 | 0.77 | CA12 (0.49) | LMNAMAPTELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608374-A1 | 2-PHENOXY- AND 2-PHENYLSULFOMAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS | Actimis Pharmaceuticals, Inc. (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004084898-A1 | 2-PHENOXY- AND 2-PHENYLSULFOMAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS | ACTIMIS PHARMACEUTICALS, INC. (US) | 2004-10-07 | — | — | WO | disclosed |