Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15956628 | 0.78 | HSPB1 (0.50) | TSHRALDH1A1HPGDTLR8EPAS1 | |
| SCHEMBL4836069 | 0.78 | HTR2A (0.49) | EPAS1TRPV4CYP3A4SLC6A2SLC6A4 | |
| SCHEMBL6425430 | 0.77 | TRPV4 (0.45) | EPAS1LMNAMAPTVEGFATRPV4 | |
| SCHEMBL11126859 | 0.76 | ALDH1A1 (0.52) | TSHRALDH1A1HPGDLMNAMAPT | |
| SCHEMBL8360646 | 0.75 | ALDH1A1 (0.43) | TSHRALDH1A1HPGDTLR8LMNA | |
| SCHEMBL997994 | 0.73 | CASP1 (0.48) | TSHRALDH1A1LMNAMAPTTDP1 | |
| SCHEMBL8360771 | 0.73 | MEN1 (0.39) | TSHRALDH1A1HPGDTBXA2REPAS1 | |
| SCHEMBL31387938 | 0.73 | TRPV4 (0.42) | ALDH1A1HPGDLMNAMAPTTDP1 | |
| SCHEMBL7205989 | 0.73 | TRPV4 (0.42) | ALDH1A1HPGDLMNAMAPTTDP1 | |
| SCHEMBL15956859 | 0.72 | HSPB1 (0.49) | TSHRALDH1A1EPAS1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958910-A | Use of N-(4-aryl-thiazol-2-yl)-sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-09-28 | — | — | US | disclosed |
| US-5877193-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0819681-A2 | N-(4-Aryl-thiazol-2-yl)-sulfonamides and their use | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-21 | — | — | EP | disclosed |