Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 14/20 | 0.62 |
| ▸ | MAOB | P27338 | 14/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.55 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.55 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6380199 | 0.90 | MAOA (0.76) | MAOAMAOBGSK3BESR1PGR | |
| SCHEMBL6385292 | 0.89 | MAOA (0.65) | MAOAMAOBHSP90AA1HSP90AB1PABPC1 | |
| SCHEMBL11071680 | 0.85 | MAOA (0.68) | MAOAMAOBHSP90AA1HSP90AB1PABPC1 | |
| SCHEMBL6380203 | 0.83 | GSK3B (0.57) | MAOAMAOBHSP90AA1HSP90AB1CASP7 | |
| Succinic Acid SCHEMBL11071592 | 0.80 | MAOA (0.61) | MAOAMAOBHSP90AA1HSP90AB1PABPC1 | |
| SCHEMBL4345333 | 0.74 | MAOA (0.83) | MAOAMAOBGSK3BESR1PGR | |
| SCHEMBL4730492 | 0.74 | MAOA (0.77) | MAOAMAOBHSP90AA1HSP90AB1ESR1 | |
| SCHEMBL11064360 | 0.73 | MAOA (0.88) | MAOAMAOBGSK3BESR1PGR | |
| SCHEMBL11066432 | 0.73 | MAOA (1.00) | MAOAMAOBGSK3BESR1PGR | |
| SCHEMBL6380623 | 0.73 | MAOA (1.00) | MAOAMAOBGSK3BESR1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0907363-A4 | 8-AMINOQUINOLINES | UNIV MISSISSIPPI (US) | 2005-04-06 | — | — | EP | claimed |
| US-20010007031-A1 | 8-AMINOQUINOLINES | UNIVERSITY OF MIAMI, THE | 2001-07-05 | — | — | US | claimed |
| EP-0907363-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1999-04-14 | — | — | EP | claimed |
| WO-1997036590-A1 | 8-AMINOQUINOLINES | THE UNIVERSITY OF MISSISSIPPI (US) | 1997-10-09 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010007031-A1 | 8-AMINOQUINOLINES | CYP2C8, COQ8A, TUBA8 | MAOA 963/4885MAOB 1272/4885HSP90AA1 4470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.