Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.36 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67181 | 0.71 | TLR7 (0.46) | — | |
| SCHEMBL24709355 | 0.67 | CHRNB2 (0.45) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL10309075 | 0.67 | GAA (0.57) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL6890038 | 0.67 | CHRNB2 (0.53) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| SCHEMBL8299077 | 0.63 | HPGD (0.66) | MAPK1GAAALDH1A1HPGDHTT | |
| SCHEMBL16870007 | 0.63 | CHRNB2 (0.57) | CHRNB2ADRA1DHTR1ECHRNA3ADRA1A | |
| 3-Methylxanthine SCHEMBL4020124 | 0.62 | ADORA2A (0.62) | MAPK1CYP3A4PMP22HPGDHSD17B10 | |
| SCHEMBL8658204 | 0.62 | MAPK1 (0.62) | MAPK1CYP3A4PMP22GAAL3MBTL1 | |
| SCHEMBL3755970 | 0.62 | RPS6KA3 (1.00) | RPS6KA3PMP22GAAALDH1A1CXCR1 | |
| Thiazolopyrimidine SCHEMBL1703410 | 0.62 | RPS6KA3 (0.52) | RPS6KA3ALDH1A1HPGDCXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6930101-B1 | Thiazolopyrimidines useful as TNFα inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-08-16 | — | — | US | disclosed |
| EP-1187838-B1 | Thiazolopyrimidines useful as TNF-Alpha inhibitors | UNIV CALIFORNIA (US) | 2003-08-06 | — | — | EP | disclosed |