Purine

Purine

SCHEMBL6426435

C[C@]1(O)C(O)O[C@H](CO)[C@H]1O.c1ncc2[nH]cnc2n1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 4/20 0.35
ADA P00813 1/20 0.31
ADORA3 P0DMS8 4/20 0.31
ADORA1 P30542 2/20 0.31
ADORA2B P29275 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ribose (Furanose) SCHEMBL5199714 0.79 ADA (0.41) ADALMNA
Ribose (Furanose) SCHEMBL27484456 0.79 ADA (0.41) ADALMNA
Ribose (Furanose) SCHEMBL4391872 0.79 ADA (0.41) ADALMNA
Purine SCHEMBL19809958 0.74 ALDH1A1 (0.39) ALDH1A1
Glucosamine SCHEMBL28890688 0.74 PYGL (0.38) ADAADORA3
Purine SCHEMBL4378871 0.73 TREH (0.33) ADA
SCHEMBL5813820 0.73 GRIN2B (0.36) ADORA2A
Purine SCHEMBL27770115 0.73 CYP3A4 (0.40) ALDH1A1LMNA
Purine SCHEMBL27575443 0.72 ALDH1A1 (0.42) ALDH1A1LMNA
SCHEMBL338344 0.72 ADORA2A (0.38) ADORA2AADAADORA3ADORA1ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1501850-A2 NUCLEOSIDE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION GENELABS TECHNOLOGIES, INC. (US) 2005-02-02 EP disclosed
US-20040063658-A1 Nucleoside derivatives for treating hepatitis C virus infection GENELABS TECHNOLOGIES, INC. 2004-04-01 US disclosed
WO-2003093290-A2 NUCLEOSIDE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION GENELABS TECHNOLOGIES, INC. (US) 2003-11-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040063658-A1 Nucleoside derivatives for treating hepatitis C virus infection HAVCR2, PNP, NTPCR ADORA2A 174/4885ADA 13/4885ADORA3 170/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.