Purine

Purine

SCHEMBL4378871

OC[C@H]1OC[C@H](O)[C@@H]1O.c1ncc2[nH]cnc2n1

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TREH O43280 1/20 0.33
ADA P00813 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ribose (Furanose) SCHEMBL4391872 0.81 ADA (0.41) ADA
Ribose (Furanose) SCHEMBL27484456 0.81 ADA (0.41) ADA
Ribose (Furanose) SCHEMBL5199714 0.81 ADA (0.41) ADA
2-Aminopurine SCHEMBL1507729 0.81 ALDH1A1 (0.55)
Purine SCHEMBL27672877 0.80
Hypoxanthine SCHEMBL4367641 0.78 LMNA (0.39)
SCHEMBL98133 0.77 HSD17B10 (0.38)
SCHEMBL9142303 0.77 LMNA (0.38)
Adenine SCHEMBL593934 0.77 PI4KA (0.54)
Mercaptopurine Anhydrous SCHEMBL1998389 0.77 LMNA (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103788160-A (2R,5R)-5-phosphoryl methoxy-2-(2-substituted adenine-9-yl)-2,5-dihydrofuran nucleoside analog as well as preparation method and application thereof UNIV ZHENGZHOU 2014-05-14 CN claimed
US-20090318556-A1 BIOMARKERS FOR DETECTING RADIATION EXPOSURE: METHODS AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2009-12-24 US claimed
EP-0036145-B1 AN ORALLY ADMINISTERED DRUG FORM COMPRISING A POLAR BIOACTIVE AGENT AND AN ADJUVANT INTERx RESEARCH CORPORATION (US) 1985-05-29 EP claimed
CN-109136314-A The method for synthesizing 2 '-deoxidation -2- amino adenosines using Michigan's Klebsiella 新乡拓新药业股份有限公司 2019-01-04 CN disclosed
CN-107083366-A Express adoptive immunity cell of hirudin and its production and use 何向锋 2017-08-22 CN disclosed
CN-103788160-A (2R,5R)-5-phosphoryl methoxy-2-(2-substituted adenine-9-yl)-2,5-dihydrofuran nucleoside analog as well as preparation method and application thereof UNIV ZHENGZHOU 2014-05-14 CN disclosed
US-20090318556-A1 BIOMARKERS FOR DETECTING RADIATION EXPOSURE: METHODS AND USES THEREOF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2009-12-24 US disclosed
US-20090299049-A1 Bicyclic Compounds and Their Use REPLIZYME LIMITED (GB) 2009-12-03 US disclosed
EP-1984455-A2 BICYCLIC COMPOUNDS AND THEIR USE THE UNIVERSITY OF YORK (GB) 2008-10-29 EP disclosed
WO-2007091056-A2 BICYCLIC COMPOUNDS AND THEIR USE THE UNIVERSITY OF YORK (GB) 2007-08-16 WO disclosed
CN-1832743-A dosage form comprising AG013736 AGOURON PHARMA (US) 2006-09-13 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090318556-A1 BIOMARKERS FOR DETECTING RADIATION EXPOSURE: METHODS AND USES THEREOF OGG1, UNG, HPRT1 TREH 854/4885ADA 777/4885
US-20090299049-A1 Bicyclic Compounds and Their Use ERCC4, PARP1, ERCC5 TREH 2974/4885ADA 505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.