Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.68 |
| ▸ | VEGFA | P15692 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997497 | 0.77 | HTR6 (0.46) | HTR6KDM4EALDH1A1CCR1 | |
| SCHEMBL1898211 | 0.70 | HTR6 (0.56) | HTR6ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL6426729 | 0.69 | HTR6 (0.47) | HTR6SLC1A3SLC1A2SLC1A1HTR1A | |
| SCHEMBL6426403 | 0.68 | HTR6 (0.48) | HTR6KDM4EALDH1A1CCR1DRD2 | |
| SCHEMBL6740915 | 0.68 | HTR6 (0.48) | HTR6KDM4EALDH1A1CCR1DRD2 | |
| SCHEMBL6426728 | 0.67 | HTR6 (0.54) | HTR6VEGFAEGLN1KDM4EALDH1A1 | |
| SCHEMBL10004175 | 0.66 | HTR6 (0.53) | HTR6SLC1A3SLC1A2SLC1A1HTR1A | |
| SCHEMBL22980669 | 0.66 | HTR6 (0.78) | HTR6ALDH1A1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL22980773 | 0.65 | HTR6 (0.58) | HTR6SLC1A3SLC1A2SLC1A1DRD2 | |
| SCHEMBL2573218 | 0.65 | MEN1 (0.60) | HTR6ALDH1A1SLC1A3SLC1A2SLC1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897215-B1 | Compounds having 5-HT6 receptor antagonist activity | NPS ALLELIX CORP. (CA) | 2005-05-24 | — | — | US | claimed |
| WO-2001032660-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR ANTAGONIST ACTIVITY | NPS ALLELIX CORP. (US) | 2001-05-10 | — | — | WO | claimed |
| US-6897215-B1 | Compounds having 5-HT6 receptor antagonist activity | NPS ALLELIX CORP. (CA) | 2005-05-24 | — | — | US | disclosed |