Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | CCR1 | P32246 | 4/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6740915 | 1.00 | HTR6 (0.48) | HTR6KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL7997497 | 0.74 | HTR6 (0.46) | HTR6KDM4EALDH1A1MAPTCCR1 | |
| SCHEMBL6744625 | 0.73 | AHR (0.42) | KDM4EALDH1A1HSD17B10HPGDCHRNA7 | |
| SCHEMBL7006323 | 0.73 | CYP1A2 (0.55) | MAPT | |
| SCHEMBL7005001 | 0.71 | HTR1A (0.47) | HTR6HTR3A | |
| SCHEMBL7501279 | 0.71 | HTR6 (0.44) | HTR6ALDH1A1CHRNA7HTR3ACNR2 | |
| SCHEMBL7006270 | 0.70 | HTR1B (0.58) | HTR6 | |
| SCHEMBL7006286 | 0.70 | HTR1B (0.58) | HTR6 | |
| SCHEMBL7006099 | 0.69 | SLC6A4 (0.53) | — | |
| SCHEMBL7010984 | 0.69 | SLC6A4 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897215-B1 | Compounds having 5-HT6 receptor antagonist activity | NPS ALLELIX CORP. (CA) | 2005-05-24 | — | — | US | disclosed |
| WO-2001032660-A1 | COMPOUNDS HAVING 5-HT6 RECEPTOR ANTAGONIST ACTIVITY | NPS ALLELIX CORP. (US) | 2001-05-10 | — | — | WO | disclosed |