Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23234735 | 0.73 | MAPT (0.45) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL27690591 | 0.72 | MAPT (0.48) | MAPTMAPK1CYP3A4HTTMEN1 | |
| SCHEMBL2976355 | 0.71 | ALDH1A1 (0.46) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL6428299 | 0.69 | MAPT (0.36) | MAPTCYP3A4HTTMEN1LMNA | |
| SCHEMBL5844440 | 0.68 | CRHR1 (0.43) | MAPTMAPK1CYP3A4 | |
| SCHEMBL6428301 | 0.68 | MAPT (0.35) | MAPTHTTMEN1LMNAKMT2A | |
| SCHEMBL6428300 | 0.68 | MEN1 (0.31) | MAPTHTTMEN1LMNAKMT2A | |
| SCHEMBL8568162 | 0.68 | MEN1 (0.38) | MAPTHTTMEN1LMNAKMT2A | |
| SCHEMBL23234743 | 0.66 | MAPT (0.41) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL9123271 | 0.65 | LMNA (0.49) | MAPTMAPK1CYP3A4HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |