Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428300 | 0.76 | MEN1 (0.31) | MAPTLMNAKMT2AHTTMEN1 | |
| SCHEMBL6428299 | 0.75 | MAPT (0.36) | MAPTHDAC3HDAC1HDAC2ALOX12 | |
| SCHEMBL6403184 | 0.69 | HCAR3 (0.40) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL6428293 | 0.68 | MAPT (0.38) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL8568162 | 0.66 | MEN1 (0.38) | MAPTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL30733379 | 0.63 | LMNA (0.40) | MAPTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL8597378 | 0.61 | MEN1 (0.41) | MAPTALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL21159495 | 0.60 | CHRM2 (0.39) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL11044330 | 0.60 | ADRB2 (0.46) | MAPTALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL9784672 | 0.60 | TDP1 (0.46) | MAPTALDH1A1LMNAKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |