Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428301 | 0.75 | MAPT (0.35) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5844444 | 0.69 | MAPT (0.37) | MAPTKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6428293 | 0.69 | MAPT (0.38) | MAPTKMT2AMEN1CYP3A4ALDH1A1 | |
| SCHEMBL27766587 | 0.68 | HTT (0.44) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6428300 | 0.68 | MEN1 (0.31) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL8601080 | 0.67 | HTT (0.43) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6403184 | 0.67 | HCAR3 (0.40) | MAPTKMT2AMEN1IDO1ALDH1A1 | |
| SCHEMBL8568162 | 0.67 | MEN1 (0.38) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8558130 | 0.65 | NOS2 (0.44) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8780888 | 0.65 | KCNH2 (0.60) | MAPTKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |