Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.33 |
| ▸ | SCN4A | P35499 | 9/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6430249 | 0.87 | SCN4A (0.33) | SCN4ASCN9AATM | |
| SCHEMBL6430830 | 0.78 | CRHR1 (0.40) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6428408 | 0.68 | CRHR1 (0.38) | MEN1KMT2AL3MBTL1SCN8ASCN4A | |
| SCHEMBL5844077 | 0.67 | CRHR1 (0.60) | — | |
| SCHEMBL1980822 | 0.65 | NOS3 (0.47) | HTR1AMEN1KMT2AL3MBTL1SCN8A | |
| SCHEMBL29922652 | 0.61 | MAPT (0.39) | MEN1KMT2ALMNACYP1A2CYP3A4 | |
| SCHEMBL21799996 | 0.61 | MAPT (0.39) | MEN1KMT2ALMNACYP1A2CYP3A4 | |
| SCHEMBL14207317 | 0.61 | GRM5 (0.39) | HTR1AADRA1DADRA1AADRA1BL3MBTL1 | |
| SCHEMBL6428372 | 0.61 | CRHR1 (0.43) | — | |
| SCHEMBL18725691 | 0.60 | FDPS (0.40) | L3MBTL1CYP1A2CYP2D6KCNH2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |