SCHEMBL6428969

SCHEMBL6428969

CCOc1ccc(P(=O)(C(=O)c2c(Cl)c(C)c(C)c(C)c2Cl)C(=O)c2c(Cl)c(C)c(C)c(C)c2Cl)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PLK1 P53350 1/20 0.41
ALDH1A1 P00352 3/20 0.40
TAS1R3 Q7RTX0 2/20 0.40
TAS1R1 Q7RTX1 2/20 0.40
KDM4E B2RXH2 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
GAA P10253 1/20 0.40
PARP10 Q53GL7 1/20 0.40
NPC1 O15118 5/20 0.39
RAB9A P51151 4/20 0.39
LMNA P02545 2/20 0.39
MAPT P10636 1/20 0.39
NQO1 P15559 1/20 0.39
POLB P06746 1/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NPSR1 Q6W5P4 1/20 0.37
MITF O75030 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL57075 0.84 TAS1R3 (0.49) PLK1ALDH1A1TAS1R3TAS1R1KDM4E
SCHEMBL58953 0.82 TAS1R3 (0.46) PLK1ALDH1A1TAS1R3TAS1R1KDM4E
SCHEMBL7033161 0.79 CHRNB2 (0.43) PLK1ALDH1A1SMN1; SMN2GAAPARP10
SCHEMBL57936 0.73 IDO1 (0.50) ALDH1A1TAS1R3TAS1R1NPC1RAB9A
SCHEMBL56880 0.69 SMN1; SMN2 (0.47) ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL28667583 0.69 RAB9A (0.51) PLK1SMN1; SMN2GAAPARP10NPC1
SCHEMBL11175437 0.68 NQO1 (0.58) PLK1ALDH1A1KDM4ESMN1; SMN2PARP10
SCHEMBL7213299 0.68 NQO1 (0.58) PLK1ALDH1A1KDM4ESMN1; SMN2PARP10
SCHEMBL20879620 0.68 NQO1 (0.58) PLK1ALDH1A1PARP10NPC1RAB9A
SCHEMBL3419802 0.64 NQO1 (0.64) PLK1ALDH1A1PARP10NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021210878-A1 CRBN-BINDING PEPTIDE AND COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER'S DISEASE USING SAME 광주과학기술원 2021-10-21 WO disclosed
WO-2019139218-A1 PHARMACEUTICAL COMPOSITION COMPRISING QUINOLINE DERIVATIVE HAVING RAS DEGRADATION ACTIVITY AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER 연세대학교 산학협력단 2019-07-18 WO disclosed
EP-1582209-B1 THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA INST MATERIA MEDICA CAMS (CN) 2012-09-19 EP disclosed
EP-1582209-A1 THE USE OF SUCCINATE DERIVATIVE ESTERS FOR THE TREATMENT OF DEMENTIA THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) 2005-10-05 EP disclosed
US-20050185232-A1 Volume hologram recording photosensitive composition and its use NIPPON PAINT CO., LTD. (JP) 2005-08-25 US disclosed