SCHEMBL6429213

SCHEMBL6429213

CC(C)(CCN1CCN(CCO)CC1)SCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
PRMT1 Q99873 1/20 0.47
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
TSHR P16473 2/20 0.44
ALDH1A1 P00352 3/20 0.42
SLC18A3 Q16572 1/20 0.41
PKM P14618 1/20 0.40
MAPK1 P28482 2/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
GAA P10253 1/20 0.40
THRB P10828 1/20 0.40
HPGD P15428 1/20 0.40
NCOA3 Q9Y6Q9 1/20 0.40
HTR2A P28223 1/20 0.39
DRD3 P35462 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6952034 0.82 TSHR (0.56) CYP1A2CYP3A4CYP2D6PRMT1MEN1
SCHEMBL19209540 0.80 CHRM2 (0.48) GAATHRBSIGMAR1
SCHEMBL7796812 0.80 CYP2D6 (0.61) CYP1A2CYP3A4CYP2D6PRMT1TSHR
SCHEMBL3037947 0.71 SIGMAR1 (0.72) KMT2ATSHRALDH1A1PKMLMNA
SCHEMBL11347486 0.71 SIGMAR1 (0.72) KMT2ATSHRALDH1A1PKMLMNA
SCHEMBL11487640 0.69 SLC6A4 (0.55) CYP2D6MEN1KMT2AALDH1A1LMNA
SCHEMBL7329630 0.68 SIGMAR1 (0.81) TSHRPOLBSIGMAR1
SCHEMBL8176858 0.68 MC4R (0.61) KMT2ATSHRALDH1A1LMNAPOLB
SCHEMBL6832085 0.68 CYP3A4 (0.46) CYP1A2CYP3A4CYP2D6PRMT1MEN1
SCHEMBL2655561 0.68 CYP1A2 (0.59) CYP1A2CYP3A4CYP2D6PRMT1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1126838-A4 NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2005-02-16 EP disclosed
EP-1126838-A1 NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE Nitromed, Inc. (US) 2001-08-29 EP disclosed
WO-2000025776-A1 NITROSATED AND NITROSYLATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-05-11 WO disclosed