Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
| ▸ | LIPE | Q05469 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24386930 | 0.84 | GAA (0.33) | ALDH1A1MAPTNPSR1GAAKMT2A | |
| SCHEMBL3804897 | 0.70 | NOS3 (0.42) | ALDH1A1KMT2A | |
| SCHEMBL5844226 | 0.70 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL6433541 | 0.69 | ALDH1A1 (0.36) | ALDH1A1POLBMAPTTLR8NPSR1 | |
| SCHEMBL5844223 | 0.68 | ALDH1A1 (0.38) | ALDH1A1POLBNR4A2TLR8CRHR1 | |
| SCHEMBL15156710 | 0.68 | ALDH1A1 (0.33) | ALDH1A1KMT2A | |
| SCHEMBL19893974 | 0.65 | ADORA2A (0.36) | ALDH1A1KDM4EL3MBTL1KMT2A | |
| SCHEMBL114512 | 0.65 | ALDH1A1 (0.32) | ALDH1A1NPSR1GAA | |
| SCHEMBL13975423 | 0.64 | HTR1A (0.46) | CA2ALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL23877913 | 0.64 | STK17A (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844351-B1 | Corticotropin releasing factor antagonists | PFIZER INC. (US) | 2005-01-18 | — | — | US | disclosed |