Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.43 |
| ▸ | TERT | O14746 | 2/20 | 0.43 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL725176 | 0.82 | PDE10A (0.54) | KDM4EGPBAR1CYSLTR1CYSLTR2ALDH1A1 | |
| Iodide SCHEMBL1343671 | 0.81 | PDE10A (0.53) | KDM4EGPBAR1CYSLTR1CYSLTR2ALDH1A1 | |
| SCHEMBL29047068 | 0.81 | PDE10A (0.53) | KDM4EGPBAR1CYSLTR1CYSLTR2ALDH1A1 | |
| SCHEMBL28709736 | 0.76 | PDE10A (0.49) | KDM4EGPBAR1CYSLTR1CYSLTR2PDE10A | |
| SCHEMBL28580709 | 0.76 | PDE10A (0.53) | KDM4EGPBAR1CYSLTR1CYSLTR2ALDH1A1 | |
| SCHEMBL10910525 | 0.76 | GPBAR1 (0.51) | GPBAR1CYSLTR1CYSLTR2ALDH1A1HPGD | |
| SCHEMBL12570780 | 0.74 | CYP1A2 (0.55) | KDM4EALDH1A1MAPTPDE10AGRM1 | |
| SCHEMBL14128956 | 0.74 | PDE10A (0.49) | KDM4EHPGDMAPTPDE10AHTR3A | |
| Sulfuric Acid SCHEMBL28294778 | 0.74 | CYP1A2 (0.50) | KDM4EGPBAR1CYSLTR1CYSLTR2MAPT | |
| SCHEMBL14127808 | 0.74 | NCF1 (0.56) | KDM4EALDH1A1HPGDMAPTPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050037090-A1 | Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent | MCKEARN JOHN P (US) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050037090-A1 | Combination therapy including a cyclooxygenase-2 inhibitor and an antineoplastic agent | PTGS2, PTGES2, PTGS1 | KDM4E 3162/4885GPBAR1 1151/4885CYSLTR1 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.