Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6438458 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL6438461 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL4631622 | 0.91 | NPC1 (0.50) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL4631618 | 0.91 | NPC1 (0.50) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL6418420 | 0.91 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1MAPTNPC1RAB9A | |
| SCHEMBL6419224 | 0.89 | RAB9A (0.44) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL6419227 | 0.89 | RAB9A (0.44) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL6419987 | 0.89 | RAB9A (0.44) | SMN1; SMN2L3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL6419890 | 0.87 | ALDH1A1 (0.43) | SMN1; SMN2MAPTMEN1KMT2ANPC1 | |
| SCHEMBL4630812 | 0.78 | MTNR1A (0.48) | L3MBTL1TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972294-B1 | Compounds, their preparation and use | NOVO NORDISK, A/S (DK) | 2005-12-06 | — | — | US | disclosed |
| EP-1171414-A1 | COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063153-A1 | NEW COMPOUNDS, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-10-26 | — | — | WO | disclosed |