Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.60 |
| ▸ | CCR2 | P41597 | 1/20 | 0.56 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420738 | 0.93 | F10 (0.70) | F10CCR2SRD5A2CNR1LTB4R | |
| SCHEMBL6432803 | 0.89 | CCR2 (0.70) | F10CCR2SRD5A2CNR1LTB4R | |
| SCHEMBL6433289 | 0.85 | NOD2 (0.67) | F10CCR2NOD2NOD1POLB | |
| SCHEMBL6433615 | 0.84 | CCR2 (0.58) | F10CCR2NOD2NOD1CNR1 | |
| SCHEMBL6432762 | 0.84 | CCR2 (0.58) | F10CCR2NOD2NOD1CNR1 | |
| SCHEMBL6432419 | 0.84 | F10 (0.71) | F10CCR2SRD5A2CNR1PPARG | |
| SCHEMBL6433663 | 0.83 | F10 (0.50) | F10CCR2NOD2NOD1POLB | |
| SCHEMBL18733284 | 0.81 | LTB4R (0.63) | F10SRD5A2LTB4RLTB4R2POLB | |
| Trifluoroacetic Acid SCHEMBL6433147 | 0.80 | CCR2 (0.54) | F10CCR2NOD2NOD1CNR1 | |
| SCHEMBL2430844 | 0.79 | SRD5A2 (0.55) | F10SRD5A2NOD2NOD1LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042287-B1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | AVENTIS PHARMA GMBH (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6337344-B1 | ANTICOAGULANTS AND ENZYME INHIBITORS FOR CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-08 | — | — | US | disclosed |
| EP-1042287-A1 | INDOLE DERIVATIVES AS INHIBITORS OF FACTOR XA | Aventis Pharma Deutschland GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999033800-A1 | INDOLE DERIVATIVES AS INHIBITORS OR FACTOR XA | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-07-08 | — | — | WO | disclosed |