Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL47863 | 0.88 | KMT2A (0.49) | MAPTHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL10993100 | 0.85 | KMT2A (0.60) | MAPTHPGDALDH1A1NPC1KMT2A | |
| SCHEMBL47864 | 0.85 | KMT2A (0.60) | MAPTHPGDALDH1A1NPC1KMT2A | |
| SCHEMBL10819670 | 0.85 | KMT2A (0.50) | MAPTHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL17147391 | 0.84 | ALDH1A1 (0.57) | MAPTHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL24465444 | 0.84 | KMT2A (0.53) | MAPTHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL12792078 | 0.83 | KMT2A (0.45) | MAPTHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL12936587 | 0.83 | RAB9A (0.52) | MAPTHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL22580675 | 0.83 | KMT2A (0.45) | MAPTHPGDALDH1A1RAB9ANPC1 | |
| SCHEMBL127279 | 0.82 | RAB9A (0.77) | MAPTHPGDALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170320867-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2017-11-09 | — | — | US | disclosed |
| US-20160031872-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2016-02-04 | — | — | US | disclosed |
| US-20140045813-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-02-13 | — | — | US | disclosed |
| US-20050054882-A1 | Diaryl ether condensation reactions | NSF - DEITR | 2005-03-10 | — | — | US | disclosed |
| US-6762329-B2 | EFFECTS OF ACIDIC ACTIVATORS ON ULLMANN-TYPE COUPLINGS INVOLVING ELECTRON-POOR AND/OR RELATIVELY INSOLUBLE SUBSTRATES. | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2004-07-13 | — | — | US | disclosed |
| US-20030088128-A1 | Diaryl ether condensation reactions | NATIONAL SCIENCE FOUNDATION | 2003-05-08 | — | — | US | disclosed |
| US-6395939-B1 | CATALYTIC ETHERIFICATION AND CONDENSATION WITH COPPER CATALYSTS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2002-05-28 | — | — | US | disclosed |
| WO-1999018057-A1 | PREPARATION OF DIARYL ETHER BY CONDENSATION REACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1999-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045813-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | MAPT 4414/4885HPGD 2600/4885ALDH1A1 3329/4885 |
| US-20050054882-A1 | Diaryl ether condensation reactions | NSFL1C, DERL1, UBE2M | MAPT 1211/4885HPGD 2359/4885ALDH1A1 1863/4885 |
| US-20030088128-A1 | Diaryl ether condensation reactions | NSFL1C, DERL1, UBE2M | MAPT 1211/4885HPGD 2359/4885ALDH1A1 1863/4885 |
| US-20170320867-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | MAPT 4414/4885HPGD 2600/4885ALDH1A1 3329/4885 |
| US-20160031872-A1 | HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS | BTK, SYK, LCK | MAPT 4414/4885HPGD 2600/4885ALDH1A1 3329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.