SCHEMBL6441045

SCHEMBL6441045

Fc1ccc(C(SCCNCC(c2ccccc2)C(F)(F)F)c2ccc(F)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 4/20 0.57
DRD4 P21917 4/20 0.57
DRD3 P35462 4/20 0.57
SLC6A3 Q01959 2/20 0.57
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
TSHR P16473 1/20 0.40
SLC6A4 P31645 1/20 0.40
CYP2C19 P33261 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoromethylbenzene SCHEMBL8846975 0.75 DRD2 (0.56) DRD2DRD4DRD3SLC6A3
SCHEMBL7437721 0.73 SLC6A3 (1.00) DRD2DRD4DRD3SLC6A3SLC6A4
SCHEMBL5994604 0.72 DRD2 (0.58) DRD2DRD4DRD3SLC6A3
SCHEMBL7424758 0.71 SLC6A3 (0.57) DRD2DRD4DRD3SLC6A3CYP1A2
SCHEMBL9829609 0.70 SLC6A3 (0.79) DRD2DRD4DRD3SLC6A3CYP1A2
SCHEMBL9771032 0.70 DRD2 (0.53) DRD2DRD4DRD3SLC6A3CYP1A2
Hydrochloric Acid SCHEMBL9771072 0.69 SLC6A3 (0.76) DRD2DRD4DRD3SLC6A3CYP1A2
SCHEMBL24676414 0.69 SLC6A3 (0.90) DRD2DRD4DRD3SLC6A3SLC6A4
SCHEMBL2498395 0.68 DRD2 (0.59) DRD2DRD4DRD3SLC6A3CYP2D6
SCHEMBL9771028 0.67 DRD2 (0.49) DRD2DRD4DRD3SLC6A3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0938305-B8 METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST ENDO PHARMACEUTICALS INC (US) 2005-10-19 EP disclosed
US-6043244-A Method and composition for treating migraine ALGOS PHARMACEUTICAL CORPORATION (US) 2000-03-28 US disclosed
EP-0942752-A1 ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN Algos Pharmaceutical Corporation (US) 1999-09-22 EP disclosed
EP-0938305-A2 METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST Algos Pharmaceutical Corporation (US) 1999-09-01 EP disclosed
WO-1998017268-A2 METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST ALGOS PHARMACEUTICAL CORPORATION (US) 1998-04-30 WO disclosed
WO-1998007447-A1 ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN ALGOS PHARMACEUTICAL CORPORATION (US) 1998-02-26 WO disclosed