Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.58 |
| ▸ | DRD4 | P21917 | 3/20 | 0.58 |
| ▸ | DRD3 | P35462 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434179 | 0.91 | SLC6A3 (0.49) | DRD2DRD4DRD3SLC6A3DAO | |
| SCHEMBL7438508 | 0.78 | SLC6A3 (0.39) | DRD2DRD4DRD3SLC6A3TACR1 | |
| SCHEMBL7443882 | 0.78 | SLC6A4 (0.60) | SLC6A3 | |
| SCHEMBL7424758 | 0.77 | SLC6A3 (0.57) | DRD2DRD4DRD3SLC6A3 | |
| SCHEMBL2498395 | 0.76 | DRD2 (0.59) | DRD2DRD4DRD3SLC6A3TACR1 | |
| SCHEMBL7437721 | 0.74 | SLC6A3 (1.00) | DRD2DRD4DRD3SLC6A3 | |
| Trifluoromethylbenzene SCHEMBL8846975 | 0.73 | DRD2 (0.56) | DRD2DRD4DRD3SLC6A3 | |
| SCHEMBL6441045 | 0.72 | DRD2 (0.57) | DRD2DRD4DRD3SLC6A3 | |
| SCHEMBL24676414 | 0.70 | SLC6A3 (0.90) | DRD2DRD4DRD3SLC6A3 | |
| SCHEMBL17329111 | 0.69 | IDO1 (0.59) | DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39300-E1 | Inhibiting the development of tolerance to and/or dependence on an addictive substance | VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL COLLEGE OF VIRGINIA (US) | 2006-09-19 | — | — | US | disclosed |
| EP-0938305-B8 | METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST | ENDO PHARMACEUTICALS INC (US) | 2005-10-19 | — | — | EP | disclosed |
| EP-0938305-B1 | METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST | ALGOS PHARM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-0942752-B1 | ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN | ALGOS PHARM CORP (US) | 2005-04-20 | — | — | EP | disclosed |
| EP-0778770-B1 | COMPOSITION ALLEVIATING PAIN, CONTAINING A NON-NARCOTIC ANALGESIC AND AN ANALGESIA ENHANCER | UNIV VIRGINIA COMMONWEALTH (US) | 2003-12-10 | — | — | EP | disclosed |
| US-6406716-B2 | Anticonvulsant containing composition for treating neuropathic pain | ENDO PHARMACEUTICALS INC. | 2002-06-18 | — | — | US | disclosed |
| EP-1146905-A1 | COX-2 INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN | Algos Pharmaceutical Corporation (US) | 2001-10-24 | — | — | EP | disclosed |
| US-20010008889-A1 | Anticonvulsant containing composition for treating neuropathic pain | ENDO PHARMACEUTICALS INC. | 2001-07-19 | — | — | US | disclosed |
| WO-2000029023-A1 | COX-2 INHIBITORS IN COMBINATION WITH NMDA-BLOCKERS FOR TREATING PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 2000-05-25 | — | — | WO | disclosed |
| US-6043244-A | Method and composition for treating migraine | ALGOS PHARMACEUTICAL CORPORATION (US) | 2000-03-28 | — | — | US | disclosed |
| WO-1998017268-A2 | METHOD OF ALLEVIATING PAIN BY MEANS OF COMBINING TRAMADOL WITH AN NMDA ANTAGONIST | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-04-30 | — | — | WO | disclosed |
| WO-1998007447-A1 | ANTICONVULSANT CONTAINING COMPOSITION FOR TREATING NEUROPATHIC PAIN | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-02-26 | — | — | WO | disclosed |
| US-5654281-A | Inhibiting the development of tolerance to and/or dependence on an addictive substance | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1997-08-05 | — | — | US | disclosed |
| US-5556838-A | BLOCKING N-METHYLASPARTATE RECEPTORS TO PREVENT ADDICTION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5502058-A | Method for the treatment of pain | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0615749-A2 | Use of NMDA antagonists for the treatment of pain | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-09-21 | — | — | EP | disclosed |
| EP-0608893-A1 | Inhibiting the development of tolerance to and/or dependence on an additive substance | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-08-03 | — | — | EP | disclosed |
| US-5321012-A | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance | VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL COLLEGE (US) | 1994-06-14 | — | — | US | disclosed |
| US-5171752-A | BENZHYDRYL DERIVATIVES HAVING CALMODULIN INHIBITOR PROPERTIES | AKZO N.V. (NL) | 1992-12-15 | — | — | US | disclosed |
| EP-0467435-A2 | Benzhydryl derivatives having calmodulin inhibitor properties | Akzo Nobel N.V. (NL) | 1992-01-22 | — | — | EP | disclosed |